Vulvar pain: Symptoms, causes, and treatment - Medication for painful vulva Like 54.62% | 807 votes Views: 356 782 Download Estrogen creams. or local anesthetics. Categories: Large Comments: Add Comment Cancel By Kazragar - 01:21 Tricyclic antidepressants. By Kajigis - 20:53 Anticonvulsants (anti-seizure medications are sometimes useful in managing chronic pain). By Zolodal - 01:01 Vulvodynia is a chronic pain condition that affects a woman's outer genitals, including the vulva. WebMD explains how vulvodynia is diagnosed. By Kazrajas - 07:35 Vulvodynia is chronic pain around the opening of your vagina in the area of your vulva. It isn't known exactly what causes it. But there's plenty.